With no further treatment, the 1996 ten-month follow-up data (n=92) from a twin mattress sale high pollen period in oregon, washington mattress and idaho together showed a greater reduction in the active group (n=43) than the placebo group (n=49) on the primary endpoint, defined as a combination of symptom and rescue medication scores.8 patients gave blood serum samples prior to the twin mattress treatment in 1995 and one year later in 1996. they were immunoassayed for specific ige antibodies using a chemi-luminescent technique. statistician bradley rosebrook ran t-tests comparing average baseline ige levels to one-year. for the seasonal allergens reported, the active group (n=27) had on average a greater reduction in ige than the placebo group (n=34) for 13 out of 16 allergens.8

in 1990 study in san diego, ca the 5 active subjects with allergic rhinitis had a lowered total serum ige from day 0 to day 90 while 4 placebo subjects, (2 with mattress allergic rhinitis, 1 with asthma twin mattress sale and 1 with both), had flat or increased ige levels.4 in a randomized, double-blind, placebo mattress controlled study of symptoms and serum ige levels in san diego, ca in mid-1991, subjects had allergic rhinitis and/or asthma. serum was drawn at day 0 and day 30. seven of the 10 active treated subjects had a reduction in total serum ige levels. in 10 placebo treated subjects, 5 had levels of total serum ige that stayed the same (plus or minus 5%), 3 decreased and 2 increased.5 statistical analysis of the open-label study as well as the double-blind randomized placebo controlled study have shown a significant effect of vitamin b12 in lowering serum ige concentrations.

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